can essentially be magnified by
the downstream processing. We will look ever so slightly deeper into this set
of mechanisms just a bit later.
At this point,
we need to note that within higher organisms, including Homo sapiens sapiens,
there are two very different classes of cells that go through the replication
process: germ cells and somatic cells. The seminal cells of a new organism, the
cells that participate in the sexual reproduction process, are termed germ
cells. For a single individual within the human species, the point of
conception involves the fusion of two germ cells, one from the female and one
from the male. These two cells combine to form the first cell of what will
become a new person; a zygote. From this cell, which contains a DNA sequence
that completely defines how to construct this new person, a series of new cells
will derive. So, changes within the DNA sequence of a germ cell, either during
the replication process or within the completed zygote prior to further
replication, can ultimately be reflected in the construction process of the
trillions of newly created cells that directly derive from the zygote in order
to form the next generation person. Hence, a change in the initial state of a
germ cell or the zygote can result in profound changes in the resulting person.
With the completion of germ cell combination, the cell structure transforms
into a somatic cell. With the
formation of the first somatic cell begins the person construction phase of
human replication. From this point, changes to the DNA molecule in any
subsequent cell will very likely be constrained to make modifications only in
that cell and its descendents; that is, the DNA changes probably won’t be
directly conveyed into changes throughout the person.
The DNA
replication process of unraveling and reconstruction occurs in discrete
sections of the DNA molecule simultaneously. Specific protein molecules attach
to the DNA strands at select points in the base pair sequences and become
markers that define the sections, while other proteins later remove these
markers from the replicated strands when the process is completed. Just as we’ll
find later on with computer systems, this parallel processing in the
replication mechanism is necessary in order to complete the operation within a
time period consistent with other, large-scale operations of the organism. Of
course, the evolutionary process actually derived the connection in the inverse
order. That is, the timing of larger scale operations, which we can observe
externally, followed the timing of the replication process of cells which
ultimately enabled all that follows.
As the double
helix unwinds, a complementary rail and base structure that is constructed from
raw materials found in the cellular interior anneals itself onto each strand
from the original DNA molecule. When reconstruction of the individual sections
is completed, a final finishing process essentially checks the accuracy of the
replication operation. The base error rate for the initial recombination is
found to be in the range of one base pair error in approximately every 10,000
base pairs replicated. Subsequent error-correcting mechanisms applied following
the initial recombination process serve to lower the effective error rate for the
full replication operation to one error in each billion base pairs. With the
subsequent fault tolerance of the cell construction from the new and old DNA
strands, this low error rate guarantees that cell duplication is a highly
reliable process. In the end, two complete DNA molecules are formed, with one
going into each of two new cells. Each of these new DNA molecules is a replica
of the original DNA molecule, so each new cell now has the same DNA blueprint
that was contained in the parent cell. This blueprint determines the function
and form of the new cell in (very roughly) the following manner.
The sequence
of base pairs found in the DNA molecule determines a code that is
translated through cellular chemistry into the construction of highly specialized
proteins at various points within a cell. Essentially, a monorail molecule
analogous to DNA, termed RNA (Ribonucleic
|